Vitamin D sufficiency, a serum 25- hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection

Interesting Research Article published in PLOS ONE September 25, 2020


The present study revealed an independent association between vitamin D sufficiency [25 (OH)D � 30 ng/mL] and decreased risk of adverse clinical outcomes from COVID-19. The severity of clinical outcomes from COVID-19 and mortality were reduced in patients who were vitamin D sufficient. Clinical features were also significantly different in patients who were vitamin D sufficient. They had a lower risk of becoming unconscious and becoming hypoxic. Patients who were vitamin D sufficient had significantly lower blood levels of the inflammatory marker CRP and had a higher total blood lymphocyte count suggesting that vitamin D sufficiency had improved the immune function in these patients and raising the inflammatory markers. This beneficial effect on the immune system may also reduce the risk of acquiring this insidious potentially life-threatening viral infection. It is recommended that further studies including RCTs are need be designed to evaluate the role of vitamin D status on risk of developing COVID-19 infection and mitigating complications and mortality in those infected with the virus. It remains debatable as to what the optimum serum level of 25(OH)D should be for maximizing its effect on the immune system. We did observe that 6.3% of the patients who had a blood level of 25(OH)D of at least 40 ng/mL succumbed to the infection compared to 9.7% and 20% who died and had a circulating blood level above and below 30 ng/mL respectively. Thus, a blood level of at least 40 ng/mL may be optimal for vitamin D’s immunomodulatory effect. Therefore, based on the available literature and results from this study it is reasonable to recommend vitamin D supplementation, along the guidelines recommended by the Endocrine Society to achieve a blood level of 25(OH)D of at least 30/mL, to children and adults to potentially reduce risk of acquiring the infection and for all COVID-19 patients especially those being admitted into the hospital.

Giovambattista Scarfone

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